Introduction: Definition drug vs toxic. Discovery and pre-clinical/clinical drug development. Pharmacovigilance.
Pharmacokinetics: drug administration routes; mechanisms of absorption, distribution, biotransformation, and elimination; Pharmacogenomics and variability of drug response (age, sex, ethnicity, comorbidities of patients).
Pharmacodynamics: different types of receptors: characteristics of the drug-receptor interactions; agonists and antagonists; dose-response relationship; therapeutic index.
Drug interactions. Main drug adverse reactions.
- Main classes of drugs acting on adrenergic, cholinergic and serotonergic transmission.
- Nods of cardiovascular pharmacology (antihypertensive).
- Anti-inflammatory and pain relievers.
- Antibiotics.
- Antivirals.
- Main classes of anticancer drugs.
Drug intoxication and abuse: opiates, cocaine, cannabis derivatives, amphetamines and amphetamines, new classes of drugs of abuse.
Ethyl alcohol intoxication: metabolic and analytical aspects.