Introduction and concepts pre-captured: review of classification and nomenclature of inorganic compounds and determination of molecular weights, R and S phrases; Expression of concentration: percent weight / weight (% w / w), weight /volume (% w / v), volume / volume (% v / v), ppm, ppb and ppt, molarity, gram-ions per liter, molality, normality, equivalent weight, dilution and mixing of solutions, electrolytes activities; solution equilibria and buffer solutions; main methods classification for quantitative classical and instrumental analysis (gravimetric and volumetric), and evaluation in terms of their precision and selectivity. Titration: neutralization, precipitation, potentiometric. Sampling and Sample Preparation: Sample preparation techniques and materials to use for the measurements of mass, volume, and their calibration. Expression of analytical data: significant figures in calculations and graphs; Conversion factors; Derived quantities and units of measure. Treatment of analytical data: systematic and random errors, mean, median, mode, Concept of precision and trueness and their evaluation; Statistical evaluation of the data and analytical techniques and their application; Straight least squares and statistics related to the processing of quantitative data . Introduction to instrumental techniques: spectrophotometric techniques for qualitative and quantitative analysis (molecular absorption spectroscopy, fluorescence, atomic spectroscopy); Chromatographic techniques (both liquid chromatography and gas chromatography) for qualitative and quantitative analysis, Introduction to analytical techniques of mass spectrometry; Validation of an analytical method according to the main International Guidelines (ICH and Bioanalytical Method Validation) for the quantitative analysis of drugs in biological matrices. Analysis of real samples: choice of the most suitable method to the analysis, matrix effect; Interfering and their elimination / reduction. Laboratory of Analytical Chemistry: statistical evaluation of a series of measurements of a salt, using an analytical balance; Preparation and subsequent dilution of standard solutions of; Extraction of two different dyes from commercial beverage by SPE technique.
