-Differences between synthetic drug and biotechnological drug.
-Overview on protein structure and nucleic acids
-RDNA technology, realization of a biotech drug.
-Techniques of analysis and purification of biological macromolecules.
✓ Identification of a "lead compound"  Screening on substances of natural origin.  Rational design.
-Combinatorial Chemistry Targeted screening
✓ Methods of optimization of a "lead compound" - molecular modifications
Prodrugs
Structure-activity relationship
✓ Pharmacokinetics (ADME) Absorption, distribution, metabolism and distribution of drugs: chemical-pharmaceutical aspects
✓ Cardioactive glycosides, antianginal and antiarrhythmic drugs
✓ Drugs active on the Renin-Angiotensin and calcium blockers
✓ Diuretics
✓ Central and peripheral sympatholytics and vasodilators (beta-blockers)
✓ Lipid-lowering drugs
✓ Antithrombotic, thrombolytic, antiplatelet and coagulant
✓ Heparin and derivatives, coumarins
✓ Fibrinolytics and antifibrinolytics
✓ Antimigraines
✓ Ergot alkaloids
✓ Antiemetics
✓ Prokinetics
✓ Irritable bowel syndrome
Drugs active on serotonergic neurotransmission
Antiulcer drugs
✓ Proton pump inhibitors