1. nucleic acid structures; genetic transmission through cell division; DNA duplication; DNA repair processes2. DNA organization within cell compartments; mitochondrial DNA structure and organization. Eucaryote gene structure and functional organization; eukaryote/prokaryote DNA structure variations. Genetic code structure and its decode. Regulation in gene expression and messenger RNA splicing.3. Gene mutations, recombination and transposone activities.4. Mendelian monogenic inheritance, genotype/phenotype correlation, sex chromosome linked genes. Mendel law exceptions, gene linkage, multifactorial inheritance.5. Chromatin structure and function, gene families and genetic polymorphisms.6. Mitosis, meiosis and cell cycle.7. Standard human karyotype. Sex chromosomes and determination of sex features. Genomic and chromosomal mutations. Chromosomal fragile sites. Chromosome banding and molecular cytogenetics.8. Hemoglobin structures and their alterations.9. Cell proliferation genes and their dysregulation. Protoncogenes, oncogenes and tumor suppressor genes.10 Genomic imprinting origin, functions and disruption. Epigenetics.11. Most recurrent genetic diseases in man.