Introduction to the course.
History, development and objectives of pharmacology.
Drugs, nutrients, nutraceuticals and health products: definitions and regulations.
Principles of general pharmacology: pharmacokinetics (absorption, distribution, metabolism and excretion; concept of bioavailability); pharmacodynamics (interaction of drugs with their molecular targets; concepts of agonist and antagonist; dose-response relationships).
Pharmacokinetic principles applied to nutrients, functional foods and food supplements.
EFFECT OF DIET ON DRUG ACTION: modification of the absorption, metabolism and elimination of drugs by the diet. Influence of drugs on nutrient absorption.
Pharmacodynamic principles applied to nutrients, functional foods and food supplements.
Factors that modify the action of drugs and nutrients: age, genetic polymorphisms, tolerance, organ disorders, microbiota; interaction between drugs and foods.
Pharmacology of food supplements
- Vitamin: Fat-soluble and water-soluble vitamin.
- Antioxidants: natural and synthetic antioxidants. Lipophilic and hydrophilic antioxidants Carotenoids, Anthocyanins.
Antioxidant vitamin.
Supplement of aminoacids/proteins; fatty acid
- Phytocompounds of the diet: flavonoids, phytosterols, phytoestrogens, glucosinolates, terpenes and plant phenols
herbs and spices.
- Macrominerals and microminerals.
-Hints on prebiotics and probiotics, intestinal microbiome
-Interactions between drugs, foods, supplements and herbal medicines
Eating behavior
- Main neurotransmitter systems involved in eating behavior and their interactions
- Neurochemical basis of compulsive food consumption
- Drugs that modulate fame and satiety.
Antidiabetic drugs and anti dislipidemic drugs