- Introduction to the course: Classification and nomenclature of inorganic compounds.
- Chemicals: classification of chemicals and their handling, Chemical risk (R and S phrases).
- Chemical equilibria. Mass measurements: (analytical balances, manipulations connected with weighing, weighing errors).
- Volume measurements (types of volumetric equipment, effect of temperature on volume measurements, calibration of volumetric glassware)
- The units of measurement of concentration: concentration expressed in physical units (percentage by weight of the solute, percentage by volume, percentage by weight / volume). Concentration expressed in chemical units (molarity, molality, normality). Mixing two solutions of the same analyte, diluting a solution, adding a solute to a solution, converting concentration units, parts per million (ppm), and parts per billion (ppb). Conversion factors, derived quantities and units of measurement.
- Errors in chemical analyzes: types of errors in experimental data. Systematic errors and their causes. Random errors, statistical treatment of random errors. The concept of precision: variance and other measures of precision, The standard deviation of calculated results (in sums and differences, in product and quotient, in exponential calculations and in logarithms). Significant digits in numerical calculations, data rounding.
- Treatment and evaluation of statistical data. Confidence intervals, accuracy comparison. Determination of gross errors: the Q test.
- Analytical samples and methods: sampling, sample types and methods, real samples, representative samples, coarse samples.
- Sample preparation techniques: LLE, SPE, SPME, SFE, MSPD, MEPS.
- Classification of the main methods of quantitative analysis: gravimetric, volumetric methods and their applications.
- Introduction to instrumental techniques: ultraviolet-visible spectroscopy and its applications. Liquid chromatography and its applications. Validation of an analytical method.
- Practical exercises in Analytical Chemistry: quantitative evaluation of an analyte of pharmaceutical interest through instrumental techniques. All the topics covered during the course are accompanied by examples and numerical exercises carried out in the classroom.
